{"product_id":"genestra-phos-choline-90c","title":"Genestra Brands Phos Choline 90c","description":"\u003cp\u003e\u003cstrong\u003eLecithin-derived phospholipid formula\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eProvides 2880 mg of phosphatides per daily dose\u003c\/li\u003e\n\u003cli\u003eSupports liver health\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cbr\u003ePhos Choline provides phospholipids that help to support liver function. Phosphatidyl-choline (PC) is the primary phospholipid (also known as phosphatide) found in lecithin.\u003csup\u003e1\u003c\/sup\u003e\u003cbr\u003eIt is an important component of cell membranes and is highly concentrated in hepatocytes.\u003csup\u003e2,3\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eAll lipoproteins are rich in PC, and are primarily produced in the liver.\u003csup\u003e3\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eNormal PC levels may help to prevent hepatic lipid accumulation as PC is necessary for the production and secretion of very low density lipoproteins (VLDL), which transport triglycerides from the liver.\u003csup\u003e2,3\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003ePC deficiencies may lead to VLDL and triglyceride buildup in the liver, which negatively affects liver function and health.\u003csup\u003e3\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eRecent\u003cspan\u003e \u003c\/span\u003e\u003cem\u003ein vitro\u003c\/em\u003e\u003cspan\u003e \u003c\/span\u003estudies show that hepatocytes also overproduce free radicals when grown in choline deficient medium; excess reactive oxygen species production can lead to DNA damage and impair liver function.\u003csup\u003e4\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eIn a randomized, double blind trial, 57 healthy adults were fed diets low in choline. After six weeks of depletion, fatty liver, liver damage and\/or muscle damage was observed among 68% of participants.\u003csup\u003e5\u003c\/sup\u003e\u003cspan\u003e \u003c\/span\u003eWhen choline was replenished in the diet, the organ dysfunction was resolved in all participants within six weeks.\u003csup\u003e5\u003c\/sup\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eREFERENCES\u003c\/strong\u003e\u003cbr\u003e\u003cspan\u003e1. Patterson KY, Bhagwat SA, Williams JR, Howe JC, Holden JM. January 2008 (http:\/\/www.ars.usda.gov\/SP2UserFiles\/Place\/80400525\/Data\/Choline\/Choln02.pdf).\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e2. Duric, M, Sivanesan, S, Bakovic, M. Eur. J. Lipid Sci. Technol. 2012; 114: 389–398.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e3. Cole, LK, Vance, JE, Vance, DE. Biochimica et Biophysica Acta. 2012; 1821: 754–761.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e4. Zeisel, SH. Mutation Research. 2012; 733: 34– 38.\u003c\/span\u003e\u003cbr\u003e\u003cspan\u003e5. Fischer, LM, daCosta, KA, Kwock, L, Stewart, PW, Lu, TS, Stabler, SP, Allen, RH, Zeisel, SH. Am J Clin Nutr. 2007; 85: 1275–85.\u003c\/span\u003e\u003c\/p\u003e","brand":"GENESTRA","offers":[{"title":"Default Title","offer_id":42264543887434,"sku":"40336","price":26.0,"currency_code":"CAD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0654\/3284\/6410\/files\/products_883196108015_en_01.png?v=1751833501","url":"https:\/\/naturesourcedeals.myshopify.com\/products\/genestra-phos-choline-90c","provider":"Nature's Source USA","version":"1.0","type":"link"}